Unique structural properties associated with mouse prion ?105-125 protein.
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ABSTRACT:
SUBMITTER: Patel A
PROVIDER: S-EPMC3783109 | biostudies-literature | 2013 May-Jun
REPOSITORIES: biostudies-literature
Publications
Unique structural properties associated with mouse prion Δ105-125 protein.
Patel Avnish A Vasiljevic Snezana S Jones Ian M IM
Prion 20130501 3
Murine prion protein deleted for residues 105-125 is intrinsically neurotoxic and mediates a TSE-like phenotype in transgenic mice. Equivalent and overlapping deletions were expressed in E.coli, purified and analyzed. Among mutants spanning the region 95-135, a construct lacking solely residues 105-125 had distinct properties when compared with the full-length prion protein 23-231 or other deletions. This distinction was also apparent followed expression in eukaryotic cells. Unlike the full-leng ...[more]
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