Ontology highlight
ABSTRACT:
SUBMITTER: Sanan TT
PROVIDER: S-EPMC3783361 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Journal of physical organic chemistry 20100401 4
The enzyme human paraoxonase 1 (huPON1) has demonstrated significant potential for use as a bioscavenger for treatment of exposure to organophosphorus (OP) nerve agents. Herein we report the development of protein models for the human isoform derived from a crystal structure of a chimeric version of the protein (pdb ID: 1V04) and a homology model derived from the related enzyme diisopropylfluorophosphatase (pdb ID: 1XHR). From these structural models, binding modes for OP substrates are predicte ...[more]