Quantifying condition-dependent intracellular protein levels enables high-precision fitness estimates.
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ABSTRACT:
SUBMITTER: Geiler-Samerotte KA
PROVIDER: S-EPMC3783400 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Quantifying condition-dependent intracellular protein levels enables high-precision fitness estimates.
Geiler-Samerotte Kerry A KA Hashimoto Tatsunori T Dion Michael F MF Budnik Bogdan A BA Airoldi Edoardo M EM Drummond D Allan DA
PloS one 20130925 9
Countless studies monitor the growth rate of microbial populations as a measure of fitness. However, an enormous gap separates growth-rate differences measurable in the laboratory from those that natural selection can distinguish efficiently. Taking advantage of the recent discovery that transcript and protein levels in budding yeast closely track growth rate, we explore the possibility that growth rate can be more sensitively inferred by monitoring the proteomic response to growth, rather than ...[more]
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