Ontology highlight
ABSTRACT:
SUBMITTER: Roman A
PROVIDER: S-EPMC3783579 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
E7 is an accessory protein that is not encoded by all papillomaviruses. The E7 amino terminus contains two regions of similarity to conserved regions 1 and 2 of the adenovirus E1A protein, which are also conserved in the simian vacuolating virus 40 large tumor antigen. The E7 carboxyl terminus consists of a zinc-binding motif, which is related to similar motifs in E6 proteins. E7 proteins play a central role in the human papillomavirus life cycle, reprogramming the cellular environment to be con ...[more]