Age-related changes of myocardial ATP supply and demand mechanisms.
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ABSTRACT:
SUBMITTER: Yaniv Y
PROVIDER: S-EPMC3783621 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Publications
Age-related changes of myocardial ATP supply and demand mechanisms.
Yaniv Yael Y Juhaszova Magdalena M Sollott Steven J SJ
Trends in endocrinology and metabolism: TEM 20130708 10
In advanced age, the resting myocardial oxygen consumption rate (MVO2) and cardiac work (CW) in the rat remain intact. However, MVO2, CW and cardiac efficiency achieved at high demand are decreased with age, compared to maximal values in the young. Whether this deterioration is due to decrease in myocardial ATP demand, ATP supply, or the control mechanisms that match them remains controversial. Here we discuss evolving perspectives of age-related changes of myocardial ATP supply and demand mecha ...[more]
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