Frequency response of a protein to local conformational perturbations.
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ABSTRACT:
SUBMITTER: Eren D
PROVIDER: S-EPMC3784495 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Frequency response of a protein to local conformational perturbations.
PLoS computational biology 20130926 9
Signals created by local perturbations are known to propagate long distances through proteins via backbone connectivity and nonbonded interactions. In the current study, signal propagation from the flexible ligand binding loop to the rest of Protein Tyrosine Phosphatase 1B (PTP1B) was investigated using frequency response techniques. Using restrained Targeted Molecular Dynamics (TMD) potential on WPD and R loops, PTP1B was driven between its crystal structure conformations at different frequenci ...[more]
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