Ontology highlight
ABSTRACT:
SUBMITTER: Waight JD
PROVIDER: S-EPMC3784535 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Waight Jeremy D JD Netherby Colleen C Hensen Mary L ML Miller Austin A Hu Qiang Q Liu Song S Bogner Paul N PN Farren Matthew R MR Lee Kelvin P KP Liu Kebin K Abrams Scott I SI
The Journal of clinical investigation 20130916 10
Myeloid-derived suppressor cells (MDSCs) comprise immature myeloid populations produced in diverse pathologies, including neoplasia. Because MDSCs can impair antitumor immunity, these cells have emerged as a significant barrier to cancer therapy. Although much research has focused on how MDSCs promote tumor progression, it remains unclear how MDSCs develop and why the MDSC response is heavily granulocytic. Given that MDSCs are a manifestation of aberrant myelopoiesis, we hypothesized that MDSCs ...[more]