Steady-state metabolite concentrations reflect a balance between maximizing enzyme efficiency and minimizing total metabolite load.
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ABSTRACT:
SUBMITTER: Tepper N
PROVIDER: S-EPMC3784570 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Steady-state metabolite concentrations reflect a balance between maximizing enzyme efficiency and minimizing total metabolite load.
Tepper Naama N Noor Elad E Amador-Noguez Daniel D Haraldsdóttir Hulda S HS Milo Ron R Rabinowitz Josh J Liebermeister Wolfram W Shlomi Tomer T
PloS one 20130926 9
Steady-state metabolite concentrations in a microorganism typically span several orders of magnitude. The underlying principles governing these concentrations remain poorly understood. Here, we hypothesize that observed variation can be explained in terms of a compromise between factors that favor minimizing metabolite pool sizes (e.g. limited solvent capacity) and the need to effectively utilize existing enzymes. The latter requires adequate thermodynamic driving force in metabolic reactions so ...[more]
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