Ontology highlight
ABSTRACT:
SUBMITTER: Harling JD
PROVIDER: S-EPMC3784729 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Harling John D JD Deakin Angela M AM Campos Sébastien S Grimley Rachel R Chaudry Laiq L Nye Catherine C Polyakova Oxana O Bessant Christina M CM Barton Nick N Somers Don D Barrett John J Graves Rebecca H RH Hanns Laura L Kerr William J WJ Solari Roberto R
The Journal of biological chemistry 20130809 39
IL-2-inducible tyrosine kinase (Itk) plays a key role in antigen receptor signaling in T cells and is considered an important target for anti-inflammatory drug discovery. In order to generate inhibitors with the necessary potency and selectivity, a compound that targeted cysteine 442 in the ATP binding pocket and with an envisaged irreversible mode of action was designed. We incorporated a high degree of molecular recognition and specific design features making the compound suitable for inhaled ...[more]