Ontology highlight
ABSTRACT:
SUBMITTER: Lange EM
PROVIDER: S-EPMC3784829 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Lange Ethan M EM Salinas Claudia A CA Zuhlke Kimberly A KA Ray Anna M AM Wang Yunfei Y Lu Yurong Y Ho Lindsey A LA Luo Jingchun J Cooney Kathleen A KA
The Prostate 20110502 2
<h4>Background</h4>Prostate cancer (PCa) affects more than 190,000 men each year with ∼10% of men diagnosed at ≤55 years, that is, early onset (EO) PCa. Based on historical findings for other cancers, EO PCa likely reflects a stronger underlying genetic etiology.<h4>Methods</h4>We evaluated the association between EO PCa and previously identified single nucleotide polymorphisms (SNPs) in 754 Caucasian cases from the Michigan Prostate Cancer Genetics Project (mean 49.8 years at diagnosis), 2,713 ...[more]