Ontology highlight
ABSTRACT:
SUBMITTER: Kristensen LS
PROVIDER: S-EPMC3784959 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Scientific reports 20130927
The tumor suppressor genes MGMT and DAPK1 become methylated in several cancers including diffuse large B-cell lymphoma (DLBCL). However, allelic methylation patterns have not been investigated in DLBCL. We developed a fast and cost-efficient method for the analysis of allelic methylation based on pyrosequencing of methylation specific PCR (MSP) products including a SNP. Allelic methylation patterns were reliably analyzed in standards of known allelic methylation status even when diluted in unmet ...[more]