Ontology highlight
ABSTRACT:
SUBMITTER: Stehling O
PROVIDER: S-EPMC3784990 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Stehling Oliver O Mascarenhas Judita J Vashisht Ajay A AA Sheftel Alex D AD Niggemeyer Brigitte B Rösser Ralf R Pierik Antonio J AJ Wohlschlegel James A JA Lill Roland R
Cell metabolism 20130725 2
Numerous cytosolic and nuclear proteins involved in metabolism, DNA maintenance, protein translation, or iron homeostasis depend on iron-sulfur (Fe/S) cofactors, yet their assembly is poorly defined. Here, we identify and characterize human CIA2A (FAM96A), CIA2B (FAM96B), and CIA1 (CIAO1) as components of the cytosolic Fe/S protein assembly (CIA) machinery. CIA1 associates with either CIA2A or CIA2B and the CIA-targeting factor MMS19. The CIA2B-CIA1-MMS19 complex binds to and facilitates assembl ...[more]