Ontology highlight
ABSTRACT:
SUBMITTER: Menaa C
PROVIDER: S-EPMC378510 | biostudies-literature | 2000 Jun
REPOSITORIES: biostudies-literature
Menaa C C Reddy S V SV Kurihara N N Maeda H H Anderson D D Cundy T T Cornish J J Singer F R FR Bruder J M JM Roodman G D GD
The Journal of clinical investigation 20000601 12
Paget's disease is characterized by highly localized areas of increased osteoclast (OCL) activity. This suggests that the microenvironment in pagetic lesions is highly osteoclastogenic, or that OCL precursors in these lesions are hyperresponsive to osteoclastogenic factors (or both). To examine these possibilities, we compared RANK ligand (RANKL) mRNA expression in a marrow stromal cell line developed from a pagetic lesion (PSV10) with that in a normal stromal cell line (Saka), and expression in ...[more]