Genome sequence, comparative analysis, and population genetics of the domestic horse.
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ABSTRACT:
SUBMITTER: Wade CM
PROVIDER: S-EPMC3785132 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Publications
Genome sequence, comparative analysis, and population genetics of the domestic horse.
Wade C M CM Giulotto E E Sigurdsson S S Zoli M M Gnerre S S Imsland F F Lear T L TL Adelson D L DL Bailey E E Bellone R R RR Blöcker H H Distl O O Edgar R C RC Garber M M Leeb T T Mauceli E E MacLeod J N JN Penedo M C T MC Raison J M JM Sharpe T T Vogel J J Andersson L L Antczak D F DF Biagi T T Binns M M MM Chowdhary B P BP Coleman S J SJ Della Valle G G Fryc S S Guérin G G Hasegawa T T Hill E W EW Jurka J J Kiialainen A A Lindgren G G Liu J J Magnani E E Mickelson J R JR Murray J J Nergadze S G SG Onofrio R R Pedroni S S Piras M F MF Raudsepp T T Rocchi M M Røed K H KH Ryder O A OA Searle S S Skow L L Swinburne J E JE Syvänen A C AC Tozaki T T Valberg S J SJ Vaudin M M White J R JR Zody M C MC Lander E S ES Lindblad-Toh K K
Science (New York, N.Y.) 20091101 5954
We report a high-quality draft sequence of the genome of the horse (Equus caballus). The genome is relatively repetitive but has little segmental duplication. Chromosomes appear to have undergone few historical rearrangements: 53% of equine chromosomes show conserved synteny to a single human chromosome. Equine chromosome 11 is shown to have an evolutionary new centromere devoid of centromeric satellite DNA, suggesting that centromeric function may arise before satellite repeat accumulation. Lin ...[more]
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