Ontology highlight
ABSTRACT:
SUBMITTER: Bai G
PROVIDER: S-EPMC3785248 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Bai Guangchun G Knapp Gwendowlyn S GS McDonough Kathleen A KA
Cellular microbiology 20101228 3
cAMP is an ancient second messenger, and is used by many organisms to regulate a wide range of cellular functions. Mycobacterium tuberculosis complex bacteria are exceptional in that they have genes for at least 15 biochemically distinct adenylyl cyclases, the enzymes that generate cAMP. cAMP-associated gene regulation within tubercle bacilli is required for their virulence, and secretion of cAMP produced by M. tuberculosis bacteria into host macrophages disrupts the host's immune response to in ...[more]