Ontology highlight
ABSTRACT:
SUBMITTER: Ohana E
PROVIDER: S-EPMC3785279 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Ohana Ehud E Shcheynikov Nikolay N Moe Orson W OW Muallem Shmuel S
Journal of the American Society of Nephrology : JASN 20130705 10
The combination of hyperoxaluria and hypocitraturia can trigger Ca(2+)-oxalate stone formation, even in the absence of hypercalciuria, but the molecular mechanisms that control urinary oxalate and citrate levels are not understood completely. Here, we examined the relationship between the oxalate transporter SLC26A6 and the citrate transporter NaDC-1 in citrate and oxalate homeostasis. Compared with wild-type mice, Slc26a6-null mice exhibited increased renal and intestinal sodium-dependent succi ...[more]