Ontology highlight
ABSTRACT:
SUBMITTER: Eisele NA
PROVIDER: S-EPMC3785333 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Eisele Nicholas A NA Ruby Thomas T Jacobson Amanda A Manzanillo Paolo S PS Cox Jeffery S JS Lam Lilian L Mukundan Lata L Chawla Ajay A Monack Denise M DM
Cell host & microbe 20130801 2
Host-adapted Salmonella strains are responsible for a number of disease manifestations in mammals, including an asymptomatic chronic infection in which bacteria survive within macrophages located in systemic sites. However, the host cell physiology and metabolic requirements supporting bacterial persistence are poorly understood. In a mouse model of long-term infection, we found that S. typhimurium preferentially associates with anti-inflammatory/M2 macrophages at later stages of infection. Furt ...[more]