Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform.
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ABSTRACT:
SUBMITTER: Gianella A
PROVIDER: S-EPMC3786364 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Publications
Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform.
Gianella Anita A Mieszawska Aneta J AJ Hoeben Freek J M FJ Janssen Henk M HM Jarzyna Peter A PA Cormode David P DP Costa Kevin D KD Rao Satish S Farokhzad Omid C OC Langer Robert R Fayad Zahi A ZA Mulder Willem J M WJ
Chemical communications (Cambridge, England) 20131001 82
We present a multifunctional nanoparticle platform that has targeting moieties shielded by a matrix metalloproteinase-2 (MMP2) cleavable PEG coating. Upon incubation with MMP2 this surface-switchable coating is removed and the targeting ligands become available for binding. The concept was evaluated in vitro using biotin and αvβ3-integrin-specific RGD-peptide functionalized nanoparticles. ...[more]
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