Dataset Information
Enantioselective direct ?-amination of aldehydes via a photoredox mechanism: a strategy for asymmetric amine fragment coupling.
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ABSTRACT:
SUBMITTER: Cecere G
PROVIDER: S-EPMC3786402 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Publications
Enantioselective direct α-amination of aldehydes via a photoredox mechanism: a strategy for asymmetric amine fragment coupling.
Journal of the American Chemical Society 20130726 31
The direct, asymmetric α-amination of aldehydes has been accomplished via a combination of photoredox and organocatalysis. Photon-generated N-centered radicals undergo enantioselective α-addition to catalytically formed chiral enamines to directly produce stable α-amino aldehyde adducts bearing synthetically useful amine substitution patterns. Incorporation of a photolabile group on the amine precursor obviates the need to employ a photoredox catalyst in this transformation. Importantly, this ph ...[more]