Ontology highlight
ABSTRACT:
SUBMITTER: Mahapatra S
PROVIDER: S-EPMC3786714 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20130711 29
The total synthesis of amphidinolide C and a second-generation synthesis of amphidinolide F have been accomplished through the use of a common intermediate to access both the C1-C8 and the C18-C25 sections. The development of a Ag-catalyzed cyclization of a propargyl benzoate diol is described to access both trans-tetrahydrofuran rings. The evolution of a Felkin-controlled, 2-lithio-1,3-dienyl addition strategy to incorporate C9-C11 diene as well as C8 stereocenter is detailed. Key controlling a ...[more]