Toxoplasma gondii exposure affects neural processing speed as measured by acoustic startle latency in schizophrenia and controls.
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ABSTRACT:
SUBMITTER: Pearce BD
PROVIDER: S-EPMC3786776 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
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Toxoplasma gondii exposure affects neural processing speed as measured by acoustic startle latency in schizophrenia and controls.
Pearce Bradley D BD Hubbard Sydney S Rivera Hilda N HN Wilkins Patricia P PP Fisch Marylynn C MC Hopkins Myfanwy H MH Hasenkamp Wendy W Gross Robin R Bliwise Nancy N Jones Jeffrey L JL Duncan Erica E
Schizophrenia research 20130813 1
The prevalence of Toxoplasma gondii (TOXO) infection in schizophrenia (SCZ) is elevated compared to controls (odds ratio=2.73). TOXO infection is associated with psychomotor slowing in rodents and non-psychiatric humans. Latency of the acoustic startle response, an index of neural processing speed, is the time it takes for a startling stimulus to elicit the reflexive response through a three-synapse subcortical circuit. We report a significant slowing of latency in TOXO seropositive SCZ vs. sero ...[more]
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