Ontology highlight
ABSTRACT:
SUBMITTER: Mezzaroba N
PROVIDER: S-EPMC3787049 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Mezzaroba Nelly N Zorzet Sonia S Secco Erika E Biffi Stefania S Tripodo Claudio C Calvaruso Marco M Mendoza-Maldonado Ramiro R Capolla Sara S Granzotto Marilena M Spretz Ruben R Larsen Gustavo G Noriega Sandra S Lucafò Marianna M Mansilla Eduardo E Garrovo Chiara C Marín Gustavo H GH Baj Gabriele G Gattei Valter V Pozzato Gabriele G Núñez Luis L Macor Paolo P
PloS one 20130930 9
Current B-cell disorder treatments take advantage of dose-intensive chemotherapy regimens and immunotherapy via use of monoclonal antibodies. Unfortunately, they may lead to insufficient tumor distribution of therapeutic agents, and often cause adverse effects on patients. In this contribution, we propose a novel therapeutic approach in which relatively high doses of Hydroxychloroquine and Chlorambucil were loaded into biodegradable nanoparticles coated with an anti-CD20 antibody. We demonstrate ...[more]