Regulation of dendritic cell differentiation in bone marrow during emergency myelopoiesis.
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ABSTRACT:
SUBMITTER: Liu H
PROVIDER: S-EPMC3787311 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Publications
Regulation of dendritic cell differentiation in bone marrow during emergency myelopoiesis.
Liu Hao H Zhou Jie J Cheng Pingyan P Ramachandran Indu I Nefedova Yulia Y Gabrilovich Dmitry I DI
Journal of immunology (Baltimore, Md. : 1950) 20130705 4
Although accumulation of dendritic cell (DC) precursors occurs in bone marrow, the terminal differentiation of these cells takes place outside bone marrow. The signaling, regulating this process, remains poorly understood. We demonstrated that this process could be differentially regulated by Notch ligands: Jagged-1 (Jag1) and Delta-like ligand 1 (Dll1). In contrast to Dll1, Jag1, in vitro and during induced myelopoiesis in vivo, prevented DC differentiation by promoting the accumulation of thei ...[more]
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