No association of 9p21 with arterial elasticity and retinal microvascular findings.
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ABSTRACT:
SUBMITTER: Folsom AR
PROVIDER: S-EPMC3787319 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Publications
No association of 9p21 with arterial elasticity and retinal microvascular findings.
Folsom Aaron R AR Pankow James S JS Li Xiaohui X Duprez Daniel A DA Jacobs David R DR Klein Ronald R Klein Barbara B Tang Weihong W Wong Tien Yin TY Cotch Mary Frances MF Taylor Kent D KD Rich Stephen S SS Hall Jennifer L JL Post Wendy S WS Rotter Jerome I JI
Atherosclerosis 20130802 2
<h4>Objective</h4>How 9p21 variation affects risk of cardiovascular disease is unclear, so we assessed whether 9p21 variants are associated with arterial elasticity or retinal microvascular findings.<h4>Methods</h4>In the prospective Multi-Ethnic Study of Atherosclerosis (MESA) we assessed 378 SNPs in the 9p21 locus. Within four ethnic groups, we used an additive genetic model to relate the 9p21 SNPs to five vascular phenotypes: small and large elasticity derived from radial diastolic pulse cont ...[more]
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