Ontology highlight
ABSTRACT:
SUBMITTER: Dick E
PROVIDER: S-EPMC3787465 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Dick Emily E Kalra Spandan S Anderson David D George Vinoj V Ritso Morten M Laval Steven H SH Barresi Rita R Aartsma-Rus Annemieke A Lochmüller Hanns H Denning Chris C
Stem cells and development 20130705 20
With an incidence of ∼1:3,500 to 5,000 in male children, Duchenne muscular dystrophy (DMD) is an X-linked disorder in which progressive muscle degeneration occurs and affected boys usually die in their twenties or thirties. Cardiac involvement occurs in 90% of patients and heart failure accounts for up to 40% of deaths. To enable new therapeutics such as gene therapy and exon skipping to be tested in human cardiomyocytes, we produced human induced pluripotent stem cells (hiPSC) from seven patien ...[more]