Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Z
PROVIDER: S-EPMC3787788 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Zhang Zhaiyi Z Falaleeva Marina M Agranat-Tamir Lily L Pages Amadis A Eyras Eduardo E Sperling Joseph J Sperling Ruth R Stamm Stefan S
Experimental brain research 20130315 4
The serotonin receptor 2C (HTR2C) gene encodes a G protein-coupled receptor that is exclusively expressed in neurons. Here, we report that the 5' untranslated region of the receptor pre-mRNA as well as its hosted miRNAs is widely expressed in non-neuronal cell lines. Alternative splicing of HTR2C is regulated by MBII-52. MBII-52 and the neighboring MBII-85 cluster are absent in people with Prader-Willi syndrome, which likely causes the disease. We show that MBII-52 and MBII-85 increase expressio ...[more]