Ontology highlight
ABSTRACT:
SUBMITTER: O'Donnell CR
PROVIDER: S-EPMC3787829 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
O'Donnell Christopher R CR Wang Hongyun H Dunbar William B WB
Electrophoresis 20130801 15
This numerical study provides an error analysis of an idealized nanopore sequencing method in which ionic current measurements are used to sequence intact single-stranded DNA in the pore, while an enzyme controls DNA motion. Examples of systematic channel errors when more than one nucleotide affects the current amplitude are detailed, which if present will persist regardless of coverage. Absent such errors, random errors associated with tracking through homopolymer regions are shown to necessita ...[more]