Treatment benefit and treatment harm rate to characterize heterogeneity in treatment effect.
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ABSTRACT:
SUBMITTER: Shen C
PROVIDER: S-EPMC3787989 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Publications
Treatment benefit and treatment harm rate to characterize heterogeneity in treatment effect.
Shen Changyu C Jeong Jaesik J Li Xiaochun X Chen Peng-Sheng PS Buxton Alfred A
Biometrics 20130719 3
It is well recognized that the conventional summary of treatment effect by averaging across individual patients has its limitation in ignoring the heterogeneous responses to the treatment in the target population. However, there are few alternative metrics in the literature that are designed to capture such heterogeneity. We propose the concept of treatment benefit rate (TBR) and treatment harm rate (THR) that characterize both the overall treatment effect and the magnitude of heterogeneity. We ...[more]
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