Unknown

Dataset Information

0

Stereospecific formation of a ternary complex of (S)-?,?-fluoromethylene-dATP with DNA pol ?.


ABSTRACT: The influence of water: crystallization of (R/S)-?,?-CHF-dATP with the preorganized pol ?-DNA complex shows that (S)-?,?-CHF-dATP is preferentially bound to the active site with the C=F fluorine proximal to a structural water bound to Asp276.

SUBMITTER: Chamberlain BT 

PROVIDER: S-EPMC3788113 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

Stereospecific formation of a ternary complex of (S)-α,β-fluoromethylene-dATP with DNA pol β.

Chamberlain Brian T BT   Batra Vinod K VK   Beard William A WA   Kadina Anastasia P AP   Shock David D DD   Kashemirov Boris A BA   McKenna Charles E CE   Goodman Myron F MF   Wilson Samuel H SH  

Chembiochem : a European journal of chemical biology 20120207 4


The influence of water: crystallization of (R/S)-α,β-CHF-dATP with the preorganized pol β-DNA complex shows that (S)-α,β-CHF-dATP is preferentially bound to the active site with the C=F fluorine proximal to a structural water bound to Asp276. ...[more]

Similar Datasets

| S-EPMC8866032 | biostudies-literature
| S-EPMC10013913 | biostudies-literature
| S-EPMC4705924 | biostudies-literature
| S-EPMC1221515 | biostudies-other
| S-EPMC4081091 | biostudies-literature
| S-EPMC2739620 | biostudies-literature
| S-EPMC3879565 | biostudies-literature
| S-EPMC2677377 | biostudies-literature
| S-EPMC2891752 | biostudies-literature
| S-EPMC3033280 | biostudies-literature