Influence of DNMT genotype on global and site specific DNA methylation patterns in neonates and pregnant women.
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ABSTRACT:
SUBMITTER: Potter C
PROVIDER: S-EPMC3788139 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Influence of DNMT genotype on global and site specific DNA methylation patterns in neonates and pregnant women.
Potter Catherine C McKay Jill J Groom Alexandra A Ford Dianne D Coneyworth Lisa L Mathers John C JC Relton Caroline L CL
PloS one 20131001 10
This study examines the relationship between common genetic variation within DNA methyltransferase genes and inter-individual variation in DNA methylation. Eleven polymorphisms spanning DNMT1 and DNMT3B were genotyped. Global and gene specific (IGF2, IGFBP3, ZNT5) DNA methylation was quantified by LUMA and bisulfite Pyrosequencing assays, respectively, in neonatal cord blood and in maternal peripheral blood. Associations between maternal genotype and maternal methylation (n (≈) 333), neonatal ge ...[more]
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