Ontology highlight
ABSTRACT:
SUBMITTER: Leigh NR
PROVIDER: S-EPMC3788140 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Leigh Noah R NR Schupp Marcus-Oliver MO Li Keguo K Padmanabhan Vakeel V Gastonguay Adam A Wang Ling L Chun Chang Z CZ Wilkinson George A GA Ramchandran Ramani R
PloS one 20131001 10
The extracellular matrix plays a critical role in neural crest (NC) cell migration. In this study, we characterize the contribution of the novel GPI-linked matrix metalloproteinase (MMP) zebrafish mmp17b. Mmp17b is expressed post-gastrulation in the developing NC. Morpholino inactivation of mmp17b function, or chemical inhibition of MMP activity results in aberrant NC cell migration with minimal change in NC proliferation or apoptosis. Intriguingly, a GPI anchored protein with metalloproteinase ...[more]