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A pilot randomized controlled trial with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom era veterans.

ABSTRACT: Subthreshold posttraumatic stress disorder (PTSD) is associated with increased risk for suicidality, depression, and functional impairment. We thus conducted a small (N=12) pilot randomized controlled trial (RCT) with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) era veterans. Hospital Anxiety and Depression Scale (HADS) scores improved by 30.4% in the paroxetine group. Paroxetine may have promise for subthreshold PTSD.

SUBMITTER: Naylor JC 

PROVIDER: S-EPMC3788578 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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A pilot randomized controlled trial with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom era veterans.

Naylor Jennifer C JC   Dolber Trygve R TR   Strauss Jennifer L JL   Kilts Jason D JD   Strauman Timothy J TJ   Bradford Daniel W DW   Szabo Steven T ST   Youssef Nagy A NA   Connor Kathryn M KM   Davidson Jonathan R T JR   Marx Christine E CE  

Psychiatry research 20121229 2-3

Subthreshold posttraumatic stress disorder (PTSD) is associated with increased risk for suicidality, depression, and functional impairment. We thus conducted a small (N=12) pilot randomized controlled trial (RCT) with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) era veterans. Hospital Anxiety and Depression Scale (HADS) scores improved by 30.4% in the paroxetine group. Paroxetine may have promise for subthreshold PTSD. ...[more]

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