Ontology highlight
ABSTRACT:
SUBMITTER: Toyama BH
PROVIDER: S-EPMC3788602 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Toyama Brandon H BH Savas Jeffrey N JN Park Sung Kyu SK Harris Michael S MS Ingolia Nicholas T NT Yates John R JR Hetzer Martin W MW
Cell 20130801 5
Intracellular proteins with long lifespans have recently been linked to age-dependent defects, ranging from decreased fertility to the functional decline of neurons. Why long-lived proteins exist in metabolically active cellular environments and how they are maintained over time remains poorly understood. Here, we provide a system-wide identification of proteins with exceptional lifespans in the rat brain. These proteins are inefficiently replenished despite being translated robustly throughout ...[more]