Ontology highlight
ABSTRACT:
SUBMITTER: Asai M
PROVIDER: S-EPMC3788688 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20130701 6143
Melanocortin receptor accessory proteins (MRAPs) modulate signaling of melanocortin receptors in vitro. To investigate the physiological role of brain-expressed melanocortin 2 receptor accessory protein 2 (MRAP2), we characterized mice with whole-body and brain-specific targeted deletion of Mrap2, both of which develop severe obesity at a young age. Mrap2 interacts directly with melanocortin 4 receptor (Mc4r), a protein previously implicated in mammalian obesity, and it enhances Mc4r-mediated ge ...[more]