Ontology highlight
ABSTRACT:
SUBMITTER: Wu Z
PROVIDER: S-EPMC3788764 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Wu Zhenqiang Z Zhang Xiaoqing X Shen Lu L Xiong Yuyu Y Wu Xi X Huo Ran R Wei Zhiyun Z Cai Lei L Qi Guoyang G Xu Qingqing Q Cui Daxiang D Cui Donghong D Zhao Gengchun G He Lin L Qin Shengying S
PloS one 20131002 10
The cytochrome P450 is the major enzyme involved in drug metabolism. Single CYP genotypes and metabolic phenotypes have been widely studied, but no combination analysis has been conducted in the context of specific populations and geographical areas. This study is the first to systematically analyze the combined genotypes and functional combinations of 400 samples of major CYP genes--CYP2E1, CYP2D6, CYP2C9, and CYP2C19 in four geographical areas of mainland China. 167 different genotype combinat ...[more]