Ontology highlight
ABSTRACT:
SUBMITTER: Fahrbach KM
PROVIDER: S-EPMC3788792 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Fahrbach Kelly M KM Malykhina Olga O Stieh Daniel J DJ Hope Thomas J TJ
PloS one 20131002 10
Cells of the endocervix are responsible for the secretion of mucins, which provide an additional layer of protection to the female reproductive tract (FRT). This barrier is likely fortified with IgA as has previously been shown in the gastrointestinal tract and lungs of mice. Mucus associated IgA can facilitate clearance of bacteria. While a similar function for IgG has been proposed, an association with mucus has not yet been demonstrated. Here we find that IgA and IgG are differentially associ ...[more]