Ontology highlight
ABSTRACT:
SUBMITTER: Mujugira A
PROVIDER: S-EPMC3789565 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Mujugira Andrew A Magaret Amalia S AS Celum Connie C Baeten Jared M JM Lingappa Jairam R JR Morrow Rhoda Ashley RA Fife Kenneth H KH Delany-Moretlwe Sinead S de Bruyn Guy G Bukusi Elizabeth A EA Karita Etienne E Kapiga Saidi S Corey Lawrence L Wald Anna A
The Journal of infectious diseases 20130730 9
<h4>Background</h4>Daily suppressive therapy with valacyclovir reduces risk of sexual transmission of herpes simplex virus type 2 (HSV-2) in HSV-2-serodiscordant heterosexual couples by 48%. Whether suppressive therapy reduces HSV-2 transmission from persons coinfected with HSV-2 and human immunodeficiency virus type 1 (HIV-1) is unknown.<h4>Methods</h4>Within a randomized trial of daily acyclovir 400 mg twice daily in African HIV-1 serodiscordant couples, in which the HIV-1-infected partner was ...[more]