Ontology highlight
ABSTRACT:
SUBMITTER: Lucas-Hourani M
PROVIDER: S-EPMC3789760 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Lucas-Hourani Marianne M Dauzonne Daniel D Jorda Pierre P Cousin Gaëlle G Lupan Alexandru A Helynck Olivier O Caignard Grégory G Janvier Geneviève G André-Leroux Gwénaëlle G Khiar Samira S Escriou Nicolas N Desprès Philippe P Jacob Yves Y Munier-Lehmann Hélène H Tangy Frédéric F Vidalain Pierre-Olivier PO
PLoS pathogens 20131003 10
Searching for stimulators of the innate antiviral response is an appealing approach to develop novel therapeutics against viral infections. Here, we established a cell-based reporter assay to identify compounds stimulating expression of interferon-inducible antiviral genes. DD264 was selected out of 41,353 compounds for both its immuno-stimulatory and antiviral properties. While searching for its mode of action, we identified DD264 as an inhibitor of pyrimidine biosynthesis pathway. This metabol ...[more]