Sex and the clinical value of body mass index in patients with clear cell renal cell carcinoma.
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ABSTRACT: Background
An increased body mass index (BMI) is significantly associated with favourable prognosis in renal cell carcinoma (RCC). This study investigated the associations among sex, BMI, and prognosis in clear cell RCC patients.Methods
We retrospectively analysed 435 patients with clear cell RCC who underwent a nephrectomy. The associations among sex, BMI, clinicopathologic factors, and cancer-specific survival (CSS) were analysed.Results
As a continuous variable, increased BMI was associated with higher CSS rate by univariate analysis in the whole population (hazard ratio, 0.888 per kg?m(-2); 95% confidence interval, 0.803-0.982; P=0.021). A sub-population analysis by sex demonstrated that BMI was significantly associated with CSS in men (P=0.004) but not in women (P=0.725). Multivariate analysis revealed BMI to be an independent predictor of CSS in only men.Conclusion
Body mass index was significantly associated with clear cell RCC prognosis. However, the clinical value of BMI may be different between men and women.
SUBMITTER: Ohno Y
PROVIDER: S-EPMC3790167 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Publications
Sex and the clinical value of body mass index in patients with clear cell renal cell carcinoma.
Ohno Y Y Nakashima J J Nakagami Y Y Satake N N Gondo T T Ohori M M Hatano T T Tachibana M M
British journal of cancer 20130903 7
<h4>Background</h4>An increased body mass index (BMI) is significantly associated with favourable prognosis in renal cell carcinoma (RCC). This study investigated the associations among sex, BMI, and prognosis in clear cell RCC patients.<h4>Methods</h4>We retrospectively analysed 435 patients with clear cell RCC who underwent a nephrectomy. The associations among sex, BMI, clinicopathologic factors, and cancer-specific survival (CSS) were analysed.<h4>Results</h4>As a continuous variable, increa ...[more]
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