Intake of coffee, caffeine and other methylxanthines and risk of Type I vs Type II endometrial cancer.
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ABSTRACT: Background
Coffee and other sources of methylxanthines and risk of Type I vs Type II endometrial cancer (EC) have not been evaluated previously.Methods
Prospective cohort of 23,356 postmenopausal women with 471 Type I and 71 Type II EC cases.Results
Type I EC was statistically significantly associated with caffeinated (relative risk (RR)=0.65 for 4+ cups per day vs ?1 cup per month: 95% confidence interval (CI): 0.47-0.89) but not decaffeinated (RR=0.76; 95% CI: 0.50-1.15) coffee intake; there were no associations with tea, cola or chocolate, or for Type II EC. The inverse association with caffeinated coffee intake was specific to women with a body mass index 30+?kg?m(-2) (RR=0.56; 95% CI: 0.36-0.89).Conclusion
Coffee may protect against Type I EC in obese postmenopausal women.
SUBMITTER: Uccella S
PROVIDER: S-EPMC3790186 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Publications
Intake of coffee, caffeine and other methylxanthines and risk of Type I vs Type II endometrial cancer.
Uccella S S Mariani A A Wang A H AH Vierkant R A RA Cliby W A WA Robien K K Anderson K E KE Cerhan J R JR
British journal of cancer 20130910 7
<h4>Background</h4>Coffee and other sources of methylxanthines and risk of Type I vs Type II endometrial cancer (EC) have not been evaluated previously.<h4>Methods</h4>Prospective cohort of 23,356 postmenopausal women with 471 Type I and 71 Type II EC cases.<h4>Results</h4>Type I EC was statistically significantly associated with caffeinated (relative risk (RR)=0.65 for 4+ cups per day vs ≤1 cup per month: 95% confidence interval (CI): 0.47-0.89) but not decaffeinated (RR=0.76; 95% CI: 0.50-1.15 ...[more]
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