Ontology highlight
ABSTRACT:
SUBMITTER: Plasman K
PROVIDER: S-EPMC3790301 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Plasman Kim K Maurer-Stroh Sebastian S Ahmad Jamshaid J Hao Han H Kaiserman Dion D Sirota Fernanda L FL Jonckheere Veronique V Bird Phillip I PI Gevaert Kris K Van Damme Petra P
Molecular & cellular proteomics : MCP 20130620 10
Granzymes are structurally related serine proteases involved in cell death and immunity. To date four out of five human granzymes have assigned orthologs in mice; however for granzyme H, no murine ortholog has been suggested and its role in cytotoxicity remains controversial. Here, we demonstrate that, as is the case for granzyme C, human granzyme H is an inefficient cytotoxin that together with their similar pattern of GrB divergence and functional similarity strongly hint to their orthologous ...[more]