Ontology highlight
ABSTRACT:
SUBMITTER: Sung KE
PROVIDER: S-EPMC3790689 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Sung Kyung Eun KE Su Xiaojing X Berthier Erwin E Pehlke Carolyn C Friedl Andreas A Beebe David J DJ
PloS one 20131004 10
The utilization of 3D, physiologically relevant in vitro cancer models to investigate complex interactions between tumor and stroma has been increasing. Prior work has generally focused on the cancer cells and, the role of fibroblast culture conditions on tumor-stromal cell interactions is still largely unknown. Here, we focus on the stroma by comparing functional behaviors of human mammary fibroblasts (HMFs) cultured in 2D and 3D and their effects on the invasive progression of breast cancer ce ...[more]