Ontology highlight
ABSTRACT:
SUBMITTER: Li YJ
PROVIDER: S-EPMC379130 | biostudies-literature | 2002 Apr
REPOSITORIES: biostudies-literature
American journal of human genetics 20020301 4
To identify genes influencing age at onset (AAO) in two common neurodegenerative diseases, a genomic screen was performed for AAO in families with Alzheimer disease (AD; n=449) and Parkinson disease (PD; n=174). Heritabilities between 40%--60% were found in both the AD and PD data sets. For PD, significant evidence for linkage to AAO was found on chromosome 1p (LOD = 3.41). For AD, the AAO effect of APOE (LOD = 3.28) was confirmed. In addition, evidence for AAO linkage on chromosomes 6 and 10 wa ...[more]