Age at onset in two common neurodegenerative diseases is genetically controlled.
Ontology highlight
ABSTRACT:
SUBMITTER: Li YJ
PROVIDER: S-EPMC379130 | biostudies-literature | 2002 Apr
REPOSITORIES: biostudies-literature
Publications
Age at onset in two common neurodegenerative diseases is genetically controlled.
Li Yi-Ju YJ Scott William K WK Hedges Dale J DJ Zhang Fengyu F Gaskell P Craig PC Nance Martha A MA Watts Ray L RL Hubble Jean P JP Koller William C WC Pahwa Rajesh R Stern Matthew B MB Hiner Bradley C BC Jankovic Joseph J Allen Fred A FA Goetz Christopher G CG Mastaglia Frank F Stajich Jeffrey M JM Gibson Rachel A RA Middleton Lefkos T LT Saunders Ann M AM Scott Burton L BL Small Gary W GW Nicodemus Kristin K KK Reed Allison D AD Schmechel Donald E DE Welsh-Bohmer Kathleen A KA Conneally P Michael PM Roses Allen D AD Gilbert John R JR Vance Jeffery M JM Haines Jonathan L JL Pericak-Vance Margaret A MA
American journal of human genetics 20020301 4
To identify genes influencing age at onset (AAO) in two common neurodegenerative diseases, a genomic screen was performed for AAO in families with Alzheimer disease (AD; n=449) and Parkinson disease (PD; n=174). Heritabilities between 40%--60% were found in both the AD and PD data sets. For PD, significant evidence for linkage to AAO was found on chromosome 1p (LOD = 3.41). For AD, the AAO effect of APOE (LOD = 3.28) was confirmed. In addition, evidence for AAO linkage on chromosomes 6 and 10 wa ...[more]
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