The long-term stability of the human gut microbiota.
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ABSTRACT:
SUBMITTER: Faith JJ
PROVIDER: S-EPMC3791589 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Publications
The long-term stability of the human gut microbiota.
Faith Jeremiah J JJ Guruge Janaki L JL Charbonneau Mark M Subramanian Sathish S Seedorf Henning H Goodman Andrew L AL Clemente Jose C JC Knight Rob R Heath Andrew C AC Leibel Rudolph L RL Rosenbaum Michael M Gordon Jeffrey I JI
Science (New York, N.Y.) 20130701 6141
A low-error 16S ribosomal RNA amplicon sequencing method, in combination with whole-genome sequencing of >500 cultured isolates, was used to characterize bacterial strain composition in the fecal microbiota of 37 U.S. adults sampled for up to 5 years. Microbiota stability followed a power-law function, which when extrapolated suggests that most strains in an individual are residents for decades. Shared strains were recovered from family members but not from unrelated individuals. Sampling of ind ...[more]
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