Ontology highlight
ABSTRACT:
SUBMITTER: Qiu L
PROVIDER: S-EPMC3791631 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Qiu Liping L Wu Cuichen C You Mingxu M Han Da D Chen Tao T Zhu Guizhi G Jiang Jianhui J Yu Ruqin R Tan Weihong W
Journal of the American Chemical Society 20130821 35
The spatiotemporal dynamics of specific mRNA molecules are difficult to image and detect inside living cells, and this has been a significant challenge for the chemical and biomedical communities. To solve this problem, we have developed a targeted, self-delivered, and photocontrolled aptamer-based molecular beacon (MB) for intracellular mRNA analysis. An internalizing aptamer connected via a double-stranded DNA structure was used as a carrier probe (CP) for cell-specific delivery of the MB desi ...[more]