Cooperation between Dmp1 loss and cyclin D1 overexpression in breast cancer.
Ontology highlight
ABSTRACT:
SUBMITTER: Zhu S
PROVIDER: S-EPMC3791682 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Publications
Cooperation between Dmp1 loss and cyclin D1 overexpression in breast cancer.
Zhu Sinan S Mott Ryan T RT Fry Elizabeth A EA Taneja Pankaj P Kulik George G Sui Guangchao G Inoue Kazushi K
The American journal of pathology 20130811 4
Cyclin D1 is a component of the core cell-cycle machinery and is frequently overexpressed in breast cancer. It physically interacts with the tumor suppressor Dmp1 that attenuates the oncogenic signals from Ras and HER2 by inducing Arf/p53-dependent cell-cycle arrest. Currently, the biological significance of Dmp1-cyclin D1 interplay in breast cancer has not been determined. Here, we show that cyclin D1 bound to Dmp1 to activate both Arf and Ink4a promoters and, consequently, induced apoptosis or ...[more]
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