MiR-184 regulates insulin secretion through repression of Slc25a22.
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ABSTRACT:
SUBMITTER: Morita S
PROVIDER: S-EPMC3792180 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
MiR-184 regulates insulin secretion through repression of Slc25a22.
Morita Sumiyo S Horii Takuro T Kimura Mika M Hatada Izuho I
PeerJ 20130924
Insulin secretion from pancreatic β-cells plays an essential role in blood glucose homeostasis and type 2 diabetes. Many genes are involved in the secretion of insulin and most of these genes can be targeted by microRNAs (miRNAs). However, the role of miRNAs in insulin secretion and type 2 diabetes has not been exhaustively studied. The expression miR-184, a miRNA enriched in pancreatic islets, negatively correlates with insulin secretion, suggesting that it is a good candidate for miRNA-mediate ...[more]
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