Ontology highlight
ABSTRACT:
SUBMITTER: Yu X
PROVIDER: S-EPMC3792401 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Yu Xinzhu X Wang Gordon G Gilmore Anthony A Yee Ada Xin AX Li Xiang X Xu Tonghui T Smith Stephen J SJ Chen Lu L Zuo Yi Y
Neuron 20131002 1
Refinement of mammalian neural circuits involves substantial experience-dependent synapse elimination. Using in vivo two-photon imaging, we found that experience-dependent elimination of postsynaptic dendritic spines in the cortex was accelerated in ephrin-A2 knockout (KO) mice, resulting in fewer adolescent spines integrated into adult circuits. Such increased spine removal in ephrin-A2 KOs depended on activation of glutamate receptors, as blockade of the N-methyl-D-aspartate (NMDA) receptors e ...[more]