Ontology highlight
ABSTRACT:
SUBMITTER: Fausti F
PROVIDER: S-EPMC3792425 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Fausti F F Di Agostino S S Cioce M M Bielli P P Sette C C Pandolfi P P PP Oren M M Sudol M M Strano S S Blandino G G
Cell death and differentiation 20130809 11
Werner syndrome (WS) results from dysfunction of the WRN protein, and is associated with premature aging and early death. Here we report that loss of WRN function elicits accumulation of the Yes-associated protein (YAP protein), a major effector of the Hippo tumor suppressor pathway, both experimentally and in WS-derived fibroblasts. YAP upregulation correlates with slower cell proliferation and accelerated senescence, which are partially mediated by the formation of a complex between YAP and th ...[more]