Ontology highlight
ABSTRACT:
SUBMITTER: Zhang L
PROVIDER: S-EPMC3792710 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Zhang Lei L Yan Feng F Zhang Shengli S Lei Dongsheng D Charles M Arthur MA Cavigiolio Giorgio G Oda Michael M Krauss Ronald M RM Weisgraber Karl H KH Rye Kerry-Anne KA Pownall Henry J HJ Qiu Xiayang X Ren Gang G
Nature chemical biology 20120219 4
Human cholesteryl ester transfer protein (CETP) mediates the net transfer of cholesteryl ester mass from atheroprotective high-density lipoproteins to atherogenic low-density lipoproteins by an unknown mechanism. Delineating this mechanism would be an important step toward the rational design of new CETP inhibitors for treating cardiovascular diseases. Using EM, single-particle image processing and molecular dynamics simulation, we discovered that CETP bridges a ternary complex with its N-termin ...[more]